{"id":6342,"date":"2025-07-01T21:27:24","date_gmt":"2025-07-01T19:27:24","guid":{"rendered":"https:\/\/akki.ut.ee\/?p=6342"},"modified":"2025-07-01T21:28:52","modified_gmt":"2025-07-01T19:28:52","slug":"publication-derivatization-for-success","status":"publish","type":"post","link":"https:\/\/akki.ut.ee\/en\/publication-derivatization-for-success\/","title":{"rendered":"Publication: Derivatization for success"},"content":{"rendered":"<div id=\"attachment_6336\" style=\"width: 251px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-6336\" class=\"wp-image-6336 \" src=\"https:\/\/akki.ut.ee\/wp-content\/uploads\/2025\/07\/Riin-Rebane-218x300.jpeg\" alt=\"\" width=\"241\" height=\"332\" srcset=\"https:\/\/akki.ut.ee\/wp-content\/uploads\/2025\/07\/Riin-Rebane-218x300.jpeg 218w, https:\/\/akki.ut.ee\/wp-content\/uploads\/2025\/07\/Riin-Rebane.jpeg 466w\" sizes=\"auto, (max-width: 241px) 100vw, 241px\" \/><p id=\"caption-attachment-6336\" class=\"wp-caption-text\">Riin Rebane<\/p><\/div>\n<p data-olk-copy-source=\"MessageBody\">Recently, a tutorial review was published in Analytica Chimica Acta by Riin Rebane and Ivo Leito, named <a href=\"https:\/\/doi.org\/10.1016\/j.aca.2025.344354\">Derivatization for success: a tutorial review of liquid chromatography mass spectrometry method optimization for determining amino compounds<\/a>. Read next what Riin has to say about the review.<\/p>\n<p data-olk-copy-source=\"MessageBody\">&#8220;This comprehensive review brings together technical depth and years of personal lab experience, shaped by long hours at the bench, countless peer discussions, and valuable lessons learned along the way. It offers a detailed, practice-oriented guide to how derivatization can dramatically improve analyte retention and ionization in LC-MS, especially for challenging amino compounds. The article dives into reagent selection, method optimization, and real-world troubleshooting &#8211; tools I wish I&#8217;d had starting out.&#8221;<\/p>\n<p>This work was supported by the Estonian Research Council grant PUT1589, and by the Estonian Ministry of Education and Research (TK210). The research was conducted using the Estonian Center of Analytical Chemistry, funded by the Estonian Research Council (TT4).<\/p>\n<div id=\"attachment_6338\" style=\"width: 679px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/analytical.chem.ut.ee\/wp-content\/uploads\/2025\/06\/Graphical_abstract_Derivatization-for-success_2025-06-29.png\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-6338\" class=\"wp-image-6338 \" src=\"https:\/\/akki.ut.ee\/wp-content\/uploads\/2025\/07\/Graphical_abstract_Derivatization-for-success_2025-06-29-300x113.png\" alt=\"\" width=\"669\" height=\"252\" srcset=\"https:\/\/akki.ut.ee\/wp-content\/uploads\/2025\/07\/Graphical_abstract_Derivatization-for-success_2025-06-29-300x113.png 300w, https:\/\/akki.ut.ee\/wp-content\/uploads\/2025\/07\/Graphical_abstract_Derivatization-for-success_2025-06-29-1024x384.png 1024w, https:\/\/akki.ut.ee\/wp-content\/uploads\/2025\/07\/Graphical_abstract_Derivatization-for-success_2025-06-29-768x288.png 768w, https:\/\/akki.ut.ee\/wp-content\/uploads\/2025\/07\/Graphical_abstract_Derivatization-for-success_2025-06-29-1536x576.png 1536w, https:\/\/akki.ut.ee\/wp-content\/uploads\/2025\/07\/Graphical_abstract_Derivatization-for-success_2025-06-29.png 1783w\" sizes=\"auto, (max-width: 669px) 100vw, 669px\" \/><\/a><p id=\"caption-attachment-6338\" class=\"wp-caption-text\">Graphical abstract for the tutorial review<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Recently, a tutorial review was published in Analytica Chimica Acta by Riin Rebane and Ivo Leito, named Derivatization for success: a tutorial review of liquid chromatography mass spectrometry method optimization&#8230;<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[54],"tags":[],"class_list":{"0":"post-6342","1":"post","2":"type-post","3":"status-publish","4":"format-standard","6":"category-news"},"_links":{"self":[{"href":"https:\/\/akki.ut.ee\/en\/wp-json\/wp\/v2\/posts\/6342","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/akki.ut.ee\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/akki.ut.ee\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/akki.ut.ee\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/akki.ut.ee\/en\/wp-json\/wp\/v2\/comments?post=6342"}],"version-history":[{"count":1,"href":"https:\/\/akki.ut.ee\/en\/wp-json\/wp\/v2\/posts\/6342\/revisions"}],"predecessor-version":[{"id":6343,"href":"https:\/\/akki.ut.ee\/en\/wp-json\/wp\/v2\/posts\/6342\/revisions\/6343"}],"wp:attachment":[{"href":"https:\/\/akki.ut.ee\/en\/wp-json\/wp\/v2\/media?parent=6342"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/akki.ut.ee\/en\/wp-json\/wp\/v2\/categories?post=6342"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/akki.ut.ee\/en\/wp-json\/wp\/v2\/tags?post=6342"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}