{"id":5438,"date":"2021-03-17T19:33:59","date_gmt":"2021-03-17T17:33:59","guid":{"rendered":"https:\/\/akki.ut.ee\/?p=5438"},"modified":"2021-03-17T19:33:59","modified_gmt":"2021-03-17T17:33:59","slug":"aminoacridines-as-matrix-materials-for-the-analysis-of-complex-samples-in-maldi-ms","status":"publish","type":"post","link":"https:\/\/akki.ut.ee\/en\/aminoacridines-as-matrix-materials-for-the-analysis-of-complex-samples-in-maldi-ms\/","title":{"rendered":"Aminoacridines as matrix materials for the analysis of complex samples in MALDI(-)-MS"},"content":{"rendered":"<p><strong>A highly interdisciplinary study ranging from computational chemistry to cultural heritage has now been published &#8211; <a href=\"https:\/\/doi.org\/10.1021\/jasms.1c00037\">Experimental and Computational Study of Aminoacridines as MALDI(-)-MS Matrix Materials for the Analysis of Complex Samples, <i>J. Am. Soc. Mass Spectrom.<\/i> 2021.<\/a>\u00a0\u00a0<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-5439 aligncenter\" src=\"https:\/\/akki.ut.ee\/wp-content\/uploads\/2021\/03\/Blogpost-17032021-300x169.png\" alt=\"\" width=\"417\" height=\"235\" srcset=\"https:\/\/akki.ut.ee\/wp-content\/uploads\/2021\/03\/Blogpost-17032021-300x169.png 300w, https:\/\/akki.ut.ee\/wp-content\/uploads\/2021\/03\/Blogpost-17032021-1024x576.png 1024w, https:\/\/akki.ut.ee\/wp-content\/uploads\/2021\/03\/Blogpost-17032021-768x432.png 768w, https:\/\/akki.ut.ee\/wp-content\/uploads\/2021\/03\/Blogpost-17032021.png 1266w\" sizes=\"auto, (max-width: 417px) 100vw, 417px\" \/><\/p>\n<p>9-aminoacridine (9-AA) is a well-known matrix material used for the MALD(-)-MS analysis. Among the other monoaminoacridines (AAs), only 3-AA has been tested once (in our cultural heritage workgroup) but the suitability of the other AAs was unknown.<\/p>\n<p>To fill this gap, the capabilities of all five AAs were studied by analysing different materials (stearic acid, colophony resin, dyer&#8217;s madder, and a resinous sample from a 16th-century shipwreck). Also, a vast range of properties for these aminoacridines were experimentally or computationally characterized (including UV-Vis absorption and fluorescence spectra, proton transfer reactions, crystallization).<\/p>\n<p>The results demonstrated, that all the AAs are suitable for the MALDI(-)-MS analysis of these materials. Interestingly, 3-AA and 4-AA outperformed the other AAs (including the best-known 9-AA) and were the preferred matrices for the analysis of samples studied in this work.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A highly interdisciplinary study ranging from computational chemistry to cultural heritage has now been published &#8211; Experimental and Computational Study of Aminoacridines as MALDI(-)-MS Matrix Materials for the Analysis of&#8230;<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":{"0":"post-5438","1":"post","2":"type-post","3":"status-publish","4":"format-standard","6":"category-uudised"},"_links":{"self":[{"href":"https:\/\/akki.ut.ee\/en\/wp-json\/wp\/v2\/posts\/5438","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/akki.ut.ee\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/akki.ut.ee\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/akki.ut.ee\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/akki.ut.ee\/en\/wp-json\/wp\/v2\/comments?post=5438"}],"version-history":[{"count":1,"href":"https:\/\/akki.ut.ee\/en\/wp-json\/wp\/v2\/posts\/5438\/revisions"}],"predecessor-version":[{"id":5441,"href":"https:\/\/akki.ut.ee\/en\/wp-json\/wp\/v2\/posts\/5438\/revisions\/5441"}],"wp:attachment":[{"href":"https:\/\/akki.ut.ee\/en\/wp-json\/wp\/v2\/media?parent=5438"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/akki.ut.ee\/en\/wp-json\/wp\/v2\/categories?post=5438"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/akki.ut.ee\/en\/wp-json\/wp\/v2\/tags?post=5438"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}