{"id":5137,"date":"2019-02-27T08:08:38","date_gmt":"2019-02-27T06:08:38","guid":{"rendered":"https:\/\/akki.ut.ee\/ut-analytical-chemistry-at-suprachem-2019-from-receptor-synthesis-to-ion-selective-electrode\/"},"modified":"2019-02-27T08:08:38","modified_gmt":"2019-02-27T06:08:38","slug":"ut-analytical-chemistry-at-suprachem-2019-from-receptor-synthesis-to-ion-selective-electrode","status":"publish","type":"post","link":"https:\/\/akki.ut.ee\/en\/ut-analytical-chemistry-at-suprachem-2019-from-receptor-synthesis-to-ion-selective-electrode\/","title":{"rendered":"UT Analytical chemistry at Suprachem 2019: From receptor synthesis to ion-selective electrode"},"content":{"rendered":"<p>During 24-26.02.2019 the <a href=\"https:\/\/www.chemie.uni-wuerzburg.de\/oc\/suprachem2019\/\">Suprachem 2019 conference<\/a> took place at University of W\u00fcrzburg (Germany). The UT Analytical chemistry chair was represented by two posters: <a href=\"http:\/\/each.ut.ee\/EACH\/wp-content\/uploads\/2019\/02\/Optimization-of-the-reaction-pathway-for-the-synthesis-of-substituted-13-biscarbazolylurea-anion-receptors.png\">Optimization of the reaction pathway for the synthesis of substituted 1,3-bis(carbazolyl)urea anion receptors<\/a> by Alo R\u00fc\u00fctel and Mihkel Ilisson and <a href=\"http:\/\/each.ut.ee\/EACH\/wp-content\/uploads\/2019\/02\/From-receptor-anion-binding-ladder-to-ion-selective-electrode.pdf\">From receptor-anion binding ladder to ion-selective electrode<\/a> by Kerli Martin, Sandip A. Kadam, Ulriika Mattinen, Johan Bobacka and Ivo Leito.<\/p>\n<p>The presentation from Alo and Mihkel focused on optimization of the synthesis route of anion receptors (ionophores) based on the 1,3-bis(carbazolyl)urea building block, augmented with additional amide functionalities (see the poster). The developed synthesis route is very valuable for the synthesis of a wide variety of analogous receptors (ionophores) that have previously been demonstrated to bind carboxylates with high affinity (see <a href=\"https:\/\/doi.org\/10.1002\/ejoc.201700931\">K. Martin et al, <em>Eur. J. Org. chem<\/em>. <strong>2017<\/strong>, 5231-5237<\/a>).<\/p>\n<p><a href=\"http:\/\/each.ut.ee\/EACH\/wp-content\/uploads\/2019\/02\/From-receptor-anion-binding-ladder-to-ion-selective-electrode.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-medium wp-image-13071\" src=\"http:\/\/each.ut.ee\/EACH\/wp-content\/uploads\/2019\/02\/From-receptor-anion-binding-ladder-to-ion-selective-electrode-212x300.jpg\" alt=\"\" width=\"212\" height=\"300\" \/><\/a>Kerli Martin et al present the first practical application of such receptors: a solid-contact acetate-selective electrodes. For acetate anion the electrodes show linearity over the activity range of 10<sup>-4.50<\/sup> \u2013 10<sup>-1.10<\/sup> with a sub-Nernstian slope of -51.3 mV per decade and a detection limit of 10<sup>-5.00<\/sup>. The anion-selectivity pattern of these electrodes deviates markedly from the pattern found in DMSO solution and from the Hofmeister pattern. The selectivity coefficients of SCN<sup>\u2013<\/sup>, I<sup>\u2013<\/sup>, NO3<sup>\u2013<\/sup> and Br<sup>\u2013<\/sup> decrease by 3-5 orders of magnitude when adding the studied ionophore to the membrane. The selectivity coefficients of hydrophilic anions such as Cl<sup>\u2013<\/sup>, F<sup>\u2013<\/sup>, HPO4<sup>2\u2013<\/sup>, and SO4<sup>2\u2013<\/sup> are significantly lower than in case of the ionophore-free control membrane. All in all, it is clear that a lot of work is still needed for improving the selectivity of the electrode.<br \/>\nThis work has been accepted for publication: <a href=\"https:\/\/doi.org\/10.1002\/elan.201800790\">K. Martin et al <em>Electroanalysis<\/em> <strong>2019<\/strong><\/a> (the link will work soon).<\/p>\n<p>The combined contributions from our group stood out from the majority (the conference altogether had 27 oral and 111 poster presentations) by a clear line of development from fundamental research (receptor design) to highly practical application (ion-selective electrode).<\/p>\n<p>(Photos: above left: Mihkel Ilisson explaining his work to Dr Diane Smith from Wiley; right: Poster by Kerli Martin et al)<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>During 24-26.02.2019 the Suprachem 2019 conference took place at University of W\u00fcrzburg (Germany). The UT Analytical chemistry chair was represented by two posters: Optimization of the reaction pathway for the&#8230;<\/p>\n","protected":false},"author":3,"featured_media":4902,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[55,58],"tags":[],"class_list":{"0":"post-5137","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-conferences","8":"category-research"},"_links":{"self":[{"href":"https:\/\/akki.ut.ee\/en\/wp-json\/wp\/v2\/posts\/5137","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/akki.ut.ee\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/akki.ut.ee\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/akki.ut.ee\/en\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/akki.ut.ee\/en\/wp-json\/wp\/v2\/comments?post=5137"}],"version-history":[{"count":0,"href":"https:\/\/akki.ut.ee\/en\/wp-json\/wp\/v2\/posts\/5137\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/akki.ut.ee\/en\/wp-json\/wp\/v2\/media\/4902"}],"wp:attachment":[{"href":"https:\/\/akki.ut.ee\/en\/wp-json\/wp\/v2\/media?parent=5137"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/akki.ut.ee\/en\/wp-json\/wp\/v2\/categories?post=5137"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/akki.ut.ee\/en\/wp-json\/wp\/v2\/tags?post=5137"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}